functional ultrasound imaging (fUSI) – Image brain activity in real time

functional ultrasound imaging (fUS/fUSI) is a versatile technology to image brain activity

at high spatiotemporal resolution, with a large field of view and depth of field.

The fUSI can be used for preclinical and clinical neuroscience research.

Cerebral Blood Volume (Power Doppler) that relates to neural activity
Cerebral Blood Flow (CBF) with quantitative RBCs velocity measurement (cortex) with color coded flow orientation (Color Doppler)
Microvascular anatomy including automated segmentation and registration of brain vasculature on the standard Atlas (available for rodents, marmosets, NHP)
Brain tissue echogenicity (B-mode) for live imaging of brain tissue and neuronavigation. This mode includes direct observation of brain infarct, tumors, hemorrhage. It is also used for image-guided intracranial injections and in vivo delivery of drugs, stem cells, or other agents.

Large-scale neural circuits imaging

fUSI is a unique technology for decoding brain activity at mesoscopic scale offering unprecedented spatio-temporal resolution (100µm/100ms), large field of view (several cm) and depth of field (up to 6.5cm). fUSi does not require contrast agent and can be used in a large variety of animal models including rodents, non-human primates and even birds.

DISCOVER THE fUSI TECHNOLOGY

Costless alternative to fMRI to study brain pathologies

Get rid of the confounding effects of anesthetics

The fUSI technology allows both measurement of brain activity and blood flow in awake and chronic conditions. fUSI is efficient to track changes over time in various pathologies, including stroke, traumatic brain injury, vascular cognitive impairment (AD, PTSD, TBI), and more.

Complementary to in vitro research

Nowadays it is impossible to mimic the entire brain in a dish. fUSI is suited for a wide range of applications, including in vivo pharmacology studies. Visualize the effects of your active compound directly in the brain using functional activity, resting-state or dynamic connectivity mapping.

APPLICATIONS

Fully compatible with electrophysiology and a wide range of techniques

fUSI is compatible with a large variety of technologies for the study of brain activity including 2-photons laser-scanning microscopy, electrophysiology with the IMEC Neuropixels, flex-polyimide and silicon probes, optogenetics, pharmacogenetics and more…