Like tens of laboratories around the world, choose AUTC for your fUSI research !
AUTC is trusted by an extensive network of scientists using the fUSI technology in academia, clinics, and industry. We have distributors in Europe and 20 major countries. Our clients benefit from the “fUSI community” supported by more than 30 principal investigators and hundreds of scientists who are regular users of the AUTC fUSI solutions. Feel free to contact us to know more and discover how fUSI can help you reach your research objectives.
Imaging of brain activity like never before
fUSI is a versatile technologies to image brain activity at high spatiotemporal resolution, with a large field of view and depth of field.
The fUSI technology is developed for preclinical and clinical neuroscience research. The AUTC HPC workstation allows both qualitative and quantitive fUSI measurement, including:
Cerebral Blood Volume (Power Doppler) that relates to neural activity
Cerebral Blood Flow (CBF) with quantitative RBCs velocity measurement (cortex) with color coded flow orientation (Color Doppler)
Microvascular anatomy including automated segmentation and registration of brain vasculature on the standard Atlas (available for rodents, marmosets, NHP)
Brain tissue echogenicity (B-mode) for live imaging of brain tissue and neuronavigation. This mode includes direct observation of brain infarct, tumors, hemorrhage. It is also used for image-guided intracranial injections and in vivo delivery of drugs, stem cells, or other agents.
Large-scale neural circuits imaging
fUSI is a unique technology for decoding brain activity at mesoscopic scale offering unprecedented spatio-temporal resolution (100µm/100ms), large field of view (several cm) and depth of field (up to 6.5cm). fUSi does not require contrast agent and can be used in a large variety of animal models including rodents, non-human primates and even birds.
Costless alternative to fMRI to study brain pathologies
Get rid of the confounding effects of anesthetics
The fUSI technology allows both measurement of brain activity and blood flow in awake and chronic conditions. fUSI is efficient to track changes over time in various pathologies, including stroke, traumatic brain injury, vascular cognitive impairment (AD, PTSD, TBI), and more.
Complementary to in vitro research
Nowadays it is impossible to mimic the entire brain in a dish. fUSI is suited for a wide range of applications, including in vivo pharmacology studies. Visualize the effects of your active compound directly in the brain using functional activity, resting-state or dynamic connectivity mapping.
Fully compatible with electrophysiology and a wide range of techniques
fUSI is compatible with a large variety of technologies for the study of brain activity including 2-photons laser-scanning microscopy, electrophysiology with the IMEC Neuropixels, flex-polyimide and silicon probes, optogenetics, pharmacogenetics and more…
Ready for clinical research
fUSI is a versatile technology for imaging brain perfusion and activity non invasively in neonates and adults for image-guided procedures
TRANSDUCER FREQUENCY
SPATIAL RESOLUTION
TEMPORAL RESOLUTION
FIELD OF VIEW
PENETRATION
Latest Publications
This section presents the recent scientific publications and news using the fUSI technology
ARTICLE| VOLUME 109, ISSUE 11, P1888-1905.E10, JUNE 02, 2021 Optogenetic fUSI for brain-wide mapping of neural activity mediating collicular-dependent behaviors [...]
NEURORESOURCE| VOLUME 108, ISSUE 5, P861-875.E7, DECEMBER 09, 2020 A Platform for Brain-wide Volumetric Functional Ultrasound Imaging and Analysis of [...]
Nature Protocols volume 16, pages 3547–3571 (2021) Abstract Most brain functions engage a network of distributed regions. Full investigation of these functions [...]
“fUSI is a breakthrough technology for real-time imaging of brain circuits dynamics at mesoscale. AUTC provides extensive service support, then it could be easily implemented both for fundamental research and in clinics.”