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Like tens of laboratories around the world, choose AUTC for your fUSI research !

AUTC is trusted by an extensive network of scientists using the fUSI technology in academia, clinics, and industry. We have distributors in Europe and 20 major countries. Our clients benefit from the “fUSI community” supported by more than 30 principal investigators and hundreds of scientists who are regular users of the AUTC fUSI solutions. Feel free to contact us to know more and discover how fUSI can help you reach your research objectives.

Image brain activity like never before

fUSI is a versatile technologies to image brain activity at high spatiotemporal resolution, with a large field of view and depth of field.

The fUSI technology is developed for preclinical and clinical neuroscience research. The AUTC fUSI scanner allows both qualitative and quantitive measurement, including:

  • Cerebral Blood Volume (Power Doppler) that relates to neural activity

  • Cerebral Blood Flow and perfusion with quantitative RBCs velocity measurement (only in the cortex) with color coded flow orientation (Color Doppler)

  • Microvascular anatomy including automated segmentation and registration of brain vasculature on the standard Atlas (available for rodents, marmosets, NHP)

  • Brain tissue echogenicity (B-mode) for live imaging of brain tissue and neuronavigation. This mode includes direct observation of brain infarct, tumors, hemorrhage. It is also used for image-guided intracranial injections and in vivo delivery of drugs, stem cells, or other agents.

OUR PRODUCTS

Large-scale neural circuits imaging

fUSI is a unique technology for decoding brain activity at mesoscopic scale offering unprecedented spatio-temporal resolution (100µm/100ms), large field of view (several cm) and depth of field (up to 6.5cm). fUSi does not require contrast agent and can be used in a large variety of animal models including rodents, non-human primates and even birds.

Costless alternative to fMRI to study brain pathologies

Get rid of the confounding effects of anesthetics

The fUSI technology allows both measurement of brain activity and blood flow in awake and chronic conditions. fUSI is efficient to track changes over time in various pathologies, including stroke, traumatic brain injury, vascular cognitive impairment (AD, PTSD, TBI), and more.

Complementary to in vitro research

Nowadays it is impossible to mimic the entire brain in a dish. fUSI is suited for a wide range of applications, including in vivo pharmacology studies. Visualize the effects of your active compound directly in the brain using functional activity, resting-state or dynamic connectivity mapping.

Full compatibility with electrophysiology and a wide range of techniques

fUSI is compatible with a large variety of technologies for the study of brain activity including 2-photons laser-scanning microscopy, electrophysiology with the IMEC Neuropixels, flex-polyimide and silicon probes, optogenetics, pharmacogenetics and more…

Clinical research

fUSI is a versatile technology for imaging brain perfusion and activity non invasively in neonates and adults for image-guided procedures

6 to 20 MHz
TRANSDUCER FREQUENCY
80 to 250 µm
SPATIAL RESOLUTION
100 ms
TEMPORAL RESOLUTION
1 to 3 cm
FIELD OF VIEW
1 to 6 cm
PENETRATION

Latest Publications

This section presents the recent scientific publications and news using the fUSI technology

Neuron 2021 – Optogenetic fUSI for brain-wide mapping of neural activity mediating collicular-dependent behaviors

ARTICLE| VOLUME 109, ISSUE 11, P1888-1905.E10, JUNE 02, 2021 Optogenetic fUSI for brain-wide mapping of neural activity mediating collicular-dependent behaviors Published:April 29, 2021DOI:https://doi.org/10.1016/j.neuron.2021.04.008 Highlights Opto-fUSI enables whole-brain analysis of functional connectivity Collicular cell types activate [...]

Neuron 2020 – A Platform for Brain-wide Volumetric Functional Ultrasound Imaging and Analysis of Circuit Dynamics in Awake Mice

NEURORESOURCE| VOLUME 108, ISSUE 5, P861-875.E7, DECEMBER 09, 2020 A Platform for Brain-wide Volumetric Functional Ultrasound Imaging and Analysis of Circuit Dynamics in Awake Mice Published:October 19, 2020DOI:https://doi.org/10.1016/j.neuron.2020.09.020 Imaging large-scale circuit dynamics is crucial to [...]

Advanced Drug Delivery Reviews 2017 – Multi-scale neurovascular imaging: advantages and limitations of multi-photon and functional ultrasound imaging

Development of efficient brain imaging technologies combining a high spatiotemporal resolution and a large penetration depth is a key step for a better understanding of the neurovascular interface that emerges as a main factor in [...]

Read latest fUSi publications

“fUSI is a breakthrough technology for real-time imaging of brain circuits dynamics at mesoscale. AUTC provides extensive service support, then it could be easily implemented both for fundamental research and in clinics.”

Dr. A. URBAN, Founder AUTC, Principal Investigator at NERF, Belgium.
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